Denitrifying bacteria form a necessary part of the process known as denitrification as part of the nitrogen cycle, their primary purpose being to metabolise nitrogenous compounds, with the assistance of the nitrate reductase enzyme, to turn oxides back to nitrogen gas or nitrous oxides for energy generation.
Chemical compounds responsible for taste are detected by human taste receptors, and the seven sensors of electronic instruments detect the same dissolved organic and inorganic compounds.
He was an early theorist of a matter theory based both on atoms and compounds.
In an HTS assay, one primary goal is to select compounds with a desired size of inhibition or activation effect.
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can display both average fold change and SSMD for all test compounds in an assay and help to integrate both of them to select hits in HTS experiments
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In a confirmatory or primary screen with replicates, for the i-th test compound with replicates, we calculate the paired difference between the measured value (usually on the log scale) of the compound and the median value of a negative control in a plate, then obtain the mean and variance of the paired difference across replicates.
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In a primary screen without replicates, assuming the measured value (usually on the log scale) in a well for a tested compound is and the negative reference in that plate has sample size , sample mean , median , standard deviation and median absolute deviation , the SSMD for this compound is estimated as
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For hit selection, the size of effects of a compound (i.e., a small molecule or an siRNA) is represented by the magnitude of difference between the compound and a negative reference.
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The size of the compound effect is represented by the magnitude of difference between a test compound and a negative reference group with no specific inhibition/activation effects.
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The other strategy is to test whether a compound has effects strong enough to reach a pre-set level.
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A compound with a desired size of effects in an HTS screen is called a hit.
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An important QC characteristic in an HTS assay is how much the positive controls, test compounds, and negative controls differ from one another in the assay.
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Leptospermone is a chemical compound (a β-triketone) produced by some members of the myrtle family (Myrtaceae), such as Callistemon citrinus (Lemon Bottlebrush), a shrub native to Australia, and Leptospermum scoparium (Manuka), a New Zealand tree from which it gets its name.
MTSL (S-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate) is a chemical compound which can be used as a nitroxide (amine oxide) paramagnetic spin label in protein Electron paramagnetic resonance spectroscopy experiments.
Solasodamine is a poisonous tetrasaccharide chemical compound of solasodine that occurs in plants of the Solanaceae family.
Solauricine is a poisonous glycoalkaloid chemical compound that occurs in plants of the Solanaceae family.