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The Academy's mission was to promote "Zoology, Botany, Geology, Mineralogy, Paleontology, Ethnology, Chemistry, Physics, Mathematics, Meteorology, Comparative Anatomy, and Physiology." Academy members started a museum collection, maintained a library, published a journal and corresponded with leading scientists of the day, providing information concerning the lands that lay adjacent and to the west of St. Louis.
In 1824 he became professor of anatomy at the College of Surgeons, delivering four annual courses of twelve lectures on comparative anatomy, using the textbook of Carl Gustav Carus.
After Cambridge he worked on the comparative anatomy of the Himalayan Hispid hare and chemotaxis in leeches, worked in Saudi Arabia studying the immobilization of Goitred and Mountain gazelles, did pupillage at the English Bar, and was a research fellow at the Hebrew University, Jerusalem.
Emil Rosenberg, working as professor, from 1876 to 1888, systematized the comparative-anatomy collections of the University of Dorpat in accordance with the system developed at the John Hunter Museum in London.
In 1861 he was Hunterian professor of comparative anatomy and physiology, and in 1863 delivered the Hunterian oration, in which he strongly put forward the neglected claims of William Hewson and John Quekett as discoverers.
He was Reader in zoology and comparative anatomy at St Bartholomew's Medical College, University of London, 1949–1960, and foundation professor of zoology and comparative physiology, then Dean of Science, at Monash University 1960-1967.
Orang-Outang, dive Homo Sylvestris: or, the Anatomy of a Pygmie Compared with that of a Monkey, an Ape, and a Man, is Edward Tyson's seminal work on anatomy, for which he became known as the father of comparative anatomy.
In 1865 he accepted the professorship of zoology at the Sorbonne, vacant through the death of Louis Pierre Gratiolet; this post he left in 1868 for the chair of comparative anatomy at the Paris museum of natural history, the anatomical collections of which were greatly enriched by his exertions.
In 1861 he became Professor of Comparative Anatomy at the University of Bologna
In 1827 he wrote notes to Henri Milne-Edwards's Surgical Anatomy, and published a second edition of Lawrence's translation of Johann Friedrich Blumenbach's Comparative Anatomy.