X-Nico

unusual facts about cystathionine beta-synthase



3-dehydroquinate synthase

However, Monsanto developed a bacterial form of EPSP synthase that was not inhibited by Roundup.

6'-Deoxychalcone synthase

Deoxychalcone synthase catalyzed activity is involved in the biosynthesis of retrochalcone and certain phytoalexins in the cells of Glycyrrhiza echinata (Russian licorice) and other leguminous plants.

Active transport

#F-ATPase: mitochondrial ATP synthase, chloroplast ATP synthase

ATP synthase gamma subunit

The human ATP synthase gamma subunit is encoded by the gene ATP5C1.

ATPC RNA motif

The RNA is always found within an operon encoding subunits of ATP synthase, and it is always located downstream of the gene encoding the A subunit of ATP synthase, and upstream of the C subunit gene.

Fatty acid synthase

Metabolism and homeostasis of fatty acid synthase is transcriptionally regulated by Upstream Stimulatory Factors (USF1 and USF2) and sterol regulatory element binding protein-1c (SREBP-1c) in response to feeding/insulin in living animals.

High-valent iron

These compounds model biological complexes such as cytochrome P450, NO synthase, and isopenicillin N synthase.

Medical genetics

Examples include the use of high doses of pyridoxine (vitamin B6) in some patients with homocystinuria to boost the activity of the residual cystathione synthase enzyme, administration of biotin to restore activity of several enzymes affected by deficiency of biotinidase, treatment with NTBC in Tyrosinemia to inhibit the production of succinylacetone which causes liver toxicity, and the use of sodium benzoate to decrease ammonia build-up in urea cycle disorders.

Reactive nitrogen species

Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (·NO) and superoxide (O2·−) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively.

Shar Pei

In the Shar-pei they discovered four small differences located in the gene HAS2 which is responsible for making hyaluronic acid synthase 2.

Transsulfuration pathway

All four transsulfuration enzymes are PLP enzymes and all bar Cystathionine γ-synthase are members of the Cys/Met metabolism PLP-dependent enzyme family (type I PLP enzymes).

In Klebsiella pneumoniae the cystathionine β-synthase is encoded by mtcB, while the γ-lyase is encoded by mtcC.


see also