X-Nico

2 unusual facts about Metabolism


Pulsatile insulin

Dr. Thomas Aoki, former Head of Metabolism Research at the Joslin Diabetes Center in Boston, Massachusetts, and a current Professor of Medicine at the University of California, Davis, was the pioneer of using pulsatile insulin in the treatment of diabetes.

Surround suppression

Therefore, surround suppression likely helps to produce a neural code that is more metabolically efficient.


ALDH1A3

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.

Benita Epstein

In addition to her studies of autism, lung surfactant, photosynthesis, purine metabolism and yellow-fever mosquitoes, she assisted her husband in ecological field research at islands around the world.

Biafra

In 2010, researchers from Karolinska Institutet in Sweden and University of Nigeria, Nsukka, showed that Igbos born in Biafra during the years of the famine were of higher risk of suffering from overweight, hypertension and impaired glucose metabolism compared to controls born a short period after the famine had ended.

C10H7NO3

Kynurenic acid, a product of the normal metabolism of amino acid L-tryptophan

Chemoton

The basic assumption of the model is that life should fundamentally and essentially have three properties: metabolism, self-replication, and a bilipid membrane.

Cyclodextrin

In 2009, research from the lab of Michael S. Brown and Joseph L. Goldstein, Nobel Prize winning scientists who pioneered the study of cholesterol metabolism, was published showing how cyclodextrin assists in moving cholesterol out of lysosomes in Niemann-Pick type C disease.

David S Rosenblatt

After completing an internship in Pediatrics at the Montreal Children's Hospital (1970–1971), he pursued postgraduate training in medical genetics and folate metabolism at the Massachusetts General Hospital under the supervision of John Littlefield and .

Denitrifying bacteria

Denitrifying bacteria form a necessary part of the process known as denitrification as part of the nitrogen cycle, their primary purpose being to metabolise nitrogenous compounds, with the assistance of the nitrate reductase enzyme, to turn oxides back to nitrogen gas or nitrous oxides for energy generation.

European Association for the Study of Diabetes

Active members receive monthly the official journal of the Association, Diabetologia, which publishes articles on clinical and experimental diabetes and metabolism.

Fatty acid synthase

Metabolism and homeostasis of fatty acid synthase is transcriptionally regulated by Upstream Stimulatory Factors (USF1 and USF2) and sterol regulatory element binding protein-1c (SREBP-1c) in response to feeding/insulin in living animals.

Glycated hemoglobin

The use of hemoglobin A1c for monitoring the degree of control of glucose metabolism in diabetic patients was proposed in 1976 by Anthony Cerami, Ronald Koenig and coworkers.

Harris–Benedict equation

The Harris–Benedict equation sprang from a study by James Arthur Harris and Francis Gano Benedict, which was published in 1919 by the Carnegie Institution of Washington in the monograph “A Biometric Study Of Basal Metabolism In Man”.

Imprinting

Metabolic imprinting, the phenomenon by which the metabolism of the developing fetus may be "programmed" during gestation

Krogh Island

The island was mapped from air photos taken by the Falkland Islands and Dependencies Aerial Survey Expedition (1956–57), and was named by the UK Antarctic Place-Names Committee for August Krogh, a Danish physiologist who specialized in the functional activity of the capillaries, and was a pioneer of studies of human metabolism and blood circulation in cold climates.

Larijani

Bagher Larijani, is an Iranian Medical Practitioner (Professor of Endocrinology) and the Director General of the Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences

Lone pair

Lead ions in the human metabolism replace native metallic ions in several key proteins, for example: zinc cations in the ALAD protein, which is also known as Porphobilinogen synthase.

Management of Crohn's disease

Budesonide is an oral corticosteroid with limited absorption and high level of first-pass metabolism, meaning that less quantities of steroid enter into the bloodstream.

Mandelic acid

Derivatives of mandelic acid are formed as a result of metabolism of adrenaline and noradrenaline by monoamine oxidase and catechol-O-methyl transferase.

Maneb

Maneb interferes with glucocorticoid metabolism by inhibiting the activity of the enzyme 11β-hydroxysteroid dehydrogenase type 2 which converts cortisol to cortisone.

Michael Stuart Brown

Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream.

Microsomal glutathione S-transferase 1

The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation.

MODY 1

In the pancreas these genes influence expression of, among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism.

Nanofoundry

In silico biology attempts to duplicate nature by creating a virtual cell with the complete cycle of metabolism.

Novus International

Early 1950s – Monsanto begins metabolism studies and the development of methionine hydroxy analogue (MHA feed supplement) production begins at Monsanto's Everett, Massachusetts location.

Opioid overdose

This includes drugs less immediately classed to a slowing of the metabolism such as with GABAergics like GHB or glutamatergic antagonists like PCP or Ketamine.

Osteocyte

Osteocyte specific proteins such as sclerostin have been shown to function in mineral metabolism, as well as other molecules such as PHEX, DMP-1, MEPE, and FGF-23, which are highly expressed by osteocytes and regulate phosphate and biomineralization.

Peripheral chemoreceptors

However, AMPK is an enzyme found in many more types of cells than chemoreceptors because it helps regulate metabolism.

The difference may actually lie in the cell’s metabolism, rather than the AMPK enzyme; peripheral chemoreceptors display very high background rates of oxygen consumption, supported by its dense network of capillaries.

Peter Hochachka

His work included studies of enzyme adaptation to temperature and pressure, the mechanisms underlying tolerance to low oxygen levels in animals, the bioenergetics of exercise, metabolism during diving in seals, allometric scaling, and human adaptations to high-altitude hypoxia.

PhiKMV-like viruses

Although phiKMV phage resembles the well-studied podovirus T7 in overall genome architecture, it was the first known T7-like phage which encoded a single-subunit RNA polymerase gene downstream its DNA metabolism genes instead of in the early genomic region.

Puran Bair

Puran Bair has worked with Dr. Herbert Benson and other researchers to document the physiological changes that occur during the different stages of meditation, including metabolism, heart rhythm, brain waves, light emission and electromagnetism.

R. palustris

Rhodopseudomonas palustris, a gram-negative purple non-sulfur bacteria, notable for its ability to switch between four different modes of metabolism.

Richard D. Feinman

Richard David Feinman (born 1940) is a professor of biochemistry and medical researcher at State University of New York Health Science Center at Brooklyn, better known as SUNY Downstate Medical Center who studies nutrition and metabolism.

Richard Tecwyn Williams

In 1949 he took up the chair of biochemistry at St Mary's Hospital Medical School in London where, in the 1950s, he worked on the metabolism of thalidomide.

Rudolph Schoenheimer

In 1933, he moved to Columbia University to join the department of Biological Chemistry and worked with David Rittenberg, from the radiochemistry laboratory of Harold C. Urey, later together with Konrad Bloch, using stable isotopes to tag foodstuffs and trace their metabolism within living things.

Salvador Moncada

He gained notoriety for his discoveries related to nitric oxide function and metabolism, and his exclusion from the 1996 Lasker Award and the 1998 Nobel Prize in medicine was strongly polemic.

Salvatore DiMauro

His research focuses on genetic errors of energy metabolism and he defines disease entities using both biochemical and molecular approaches.

Serono

Serono as a stand-alone company develops and markets pharmaceuticals in the fields of Reproductive Health, Multiple Sclerosis, Growth & Metabolism and Dermatology.

Stephen Szára

In the U.S., he worked with Julius Axelrod and others on the metabolism of DMT and related compounds in healthy and schizophrenic volunteers.

STS-58

The experiment, sponsored by Dr. C.D. Arnaud of the University of California at San Francisco, studies the mechanisms of how calcium is maintained and used in bone metabolism in space.

Sylvester Sanfilippo

These observations indicated the existence of a new inborn error of the mucopolysaccharide metabolism.

Tak Wah Mak

Mak, Lewis C. Cantley, and Craig B. Thompson together founded Agios, a biotech pharmaceutical company whose sole purpose is to discover methods of targeting cancer metabolism.

Thaddeus Mann

Mann began his career in the laboratory of Professor Jacob Karol Parnas (1884-1949) in Poland, where he was involved in research on glycolysis and muscle energy metabolism.

Transsulfuration pathway

All four transsulfuration enzymes are PLP enzymes and all bar Cystathionine γ-synthase are members of the Cys/Met metabolism PLP-dependent enzyme family (type I PLP enzymes).

Željko Reiner

He is the member of the editorial boards of several international journals such as: Nature Reviews Cardiology, Atherosclerosis (journal), Nutrition, Metabolism & Cardiovascular Diseases and other.


see also