From 1970-80 he analysed T-T Cell interactions during the induction of cytotoxic T Cell responses <1>.
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This results in a change in immunological tolerance and the subsequent activation of abacavir-specific cytotoxic T cells, which produce a systemic reaction known as abacavir hypersensitivity syndrome.
Granulysin is a substance released by cytotoxic T cells (CD8) when they are attached to infected body cells.