In 1856, German physician and pathologist Rudolf Virchow published what is referred to as Virchow's triad, the three major causes of thrombosis.
Increased and decreased levels of γA/γ' fibrinogen have been associated with CAD and DVT respectively.
After returning to the Czech Republic in the off-season, Fleischmann was found to have developed a blood clot in his leg due to Deep vein thrombosis from the cross-Atlantic flight and would miss the pre-season and the start of the 2009–10 season.
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Louvel's sign is a clinical sign found in patients with deep vein thrombosis.