Neuroblastoma RAS viral oncogene homolog | Diablo homolog | COP9 constitutive photomorphogenic homolog subunit 5 |
It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.
Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.
This gene encodes a DEAD box protein, and it has a homolog on the X chromosome (DDX3X).
Finally, DNMT2 (TRDMT1) has been identified as a DNA methyltransferase homolog, containing all 10 sequence motifs common to all DNA methyltransferases; however, DNMT2 (TRDMT1) does not methylate DNA but instead methylates cytosine-38 in the anticodon loop of aspartic acid transfer RNA.
PDE4DIP encodes a centrosomal protein and is a homolog of CDK5RAP2, a gene that lacks DUF1220 sequences and, when mutated, has been implicated in microcephaly.
EF-P is the prokaryotic homolog of eIF5A, which is also modified post-translationally in a similar but distinct way.
FAM46C and specifically the DUF1693 is traceable throughout the known metazoans, with a distant homolog found in Trichoplax adhaerens, a member of the basal multicellular organismal group Placozoa.
The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression.
The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH1) gene expression.
Human jagged 1 is the ligand for the receptor Notch-1, the latter a human homolog of the Drosophilia jagged receptor notch.
Among his laboratory's many subsequent discoveries, he is recognized for the cloning of the patched gene family and demonstration that a human homolog PTCH1 is a key tumor suppressor gene for the Hedgehog signaling pathway as well as the causative gene for the nevoid basal cell carcinoma syndrome, or Gorlin syndrome.
miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells.
Notch-2 (Neurogenic locus notch homolog protein 2) is a protein that in humans is encoded by the NOTCH2 gene.
As an example, the brachyury gene and the homolog of the PAX2 gene both play a similar role in the development of tunicates as they do in vertebrates.
CLOCK (circadian locomotor output cycles kaput) was first cloned in mouse and BMAL1 (brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like 1) is the primary homolog of Drosophila CYC.