antibody | Antibody | intracellular | Anti-neutrophil cytoplasmic antibody | Single-domain antibody | Intracellular | Humanized antibody | Anti-nuclear antibody | Anti-glomerular basement membrane antibody | Anti-citrullinated protein antibody | Antibody therapy | Antibody-drug conjugate | antibody-dependent cell-mediated cytotoxicity |
IgG also plays an important role in antibody-dependent cell-mediated cytotoxicity (ADCC) and intracellular antibody-mediated proteolysis, in which it binds to TRIM21 (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol.
Intracellular antibody-mediated degradation (IAMD) is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded.