Intracellular antibody-mediated degradation (IAMD) is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded.
antibody | Antibody | intracellular | environmental degradation | Anti-neutrophil cytoplasmic antibody | UV degradation | Single-domain antibody | Intracellular | Humanized antibody | Endoplasmic-reticulum-associated protein degradation | Edman degradation | Anti-nuclear antibody | Anti-glomerular basement membrane antibody | Anti-citrullinated protein antibody | Antibody therapy | Antibody-drug conjugate | antibody-dependent cell-mediated cytotoxicity |
IgG also plays an important role in antibody-dependent cell-mediated cytotoxicity (ADCC) and intracellular antibody-mediated proteolysis, in which it binds to TRIM21 (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol.