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Methemoglobinemia has also been seen, although it is typically responsive to treatment with methylene blue.
A blue cocktail was also served, a combination of gin, Cointreau, and methylene blue, which, much to Klein’s surprise and delight, caused his patrons to urinate blue the next day.
Leuco dyes are a key component of some thermochromic dyes and thermal printer papers, photochromic materials, and of the Flexplay DVD discs with limited play time, where leuco form of methylene blue is used.
Working with Hope Sherman, Gladys Leavell, and Lauretta Bender, among others, DeWitt examined several dyes as potential precursors to an anti-tuberculosis drug, including methylene blue and trypan red.
The test is based on the presence of certain antibodies that prevent methylene blue dye from entering the cytoplasm of Toxoplasma organisms.
Methylthioninium chloride (INN, or methylene blue, proposed trade name Rember) is an investigational drug being developed by the University of Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau protein aggregation.
In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key mitochondrial biochemical pathways.
The demethylation of Methylene Blue in aqueous solution using heat and alkali produces a mixture of Azure A, Azure B, Methylene Violet and Methylene Blue.