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Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with ISL1 in early motor neuron differentiation and has a suggested role in the ISL1 dependent development of motor neurons.
Spasms can be caused by a disparity between how much alpha and gamma motor neurons are firing i.e. too much gain of one or the other.
Spike-triggered averaging is a way to measure the activity of one cortical motor neuron, on a group of lower motor neurons in the spinal cord.
#Somatic motor control - Some motor neurons send their axons to the reticular formation nuclei, giving rise to the reticulospinal tracts of the spinal cord.
A lack of SMN due to SMN1 deletion results in widespread splicing defects, especially in spinal motor neurons, and is one cause of spinal muscular atrophy.