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Staging of Bas-LCLC patients is usually performed in an analogous fashion to patients with other non-small cell lung carcinoma.
About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion gene between EML4 ('echinoderm microtubule-associated protein-like 4') and ALK ('anaplastic lymphoma kinase'), which results in constitutive kinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype.
:Endocyte, a pharmaceutical company, is developing EC145 (Vintafolide), a candidate drug for use in chemotherapy-resistant patients with non-small-cell lung cancer.