In 2012 SETBP1 was identified as a novel oncogene in aCML; specific somatic mutations of this gene were discovered in patients affected by atypical Chronic Myeloid Leukemia (aCML) and related diseases.
In 2012 Dr. Gambacorti-Passerini discovered SETBP1 as a novel oncogene and identified specific mutations of this gene in patients affected by atypical Chronic Myeloid Leukemia (aCML).
Establishment of Tg-rasH2 mouse, in which a human prototype c-Ha-ras oncogene is introduced, and evaluation of their practical usefulness.
He is best known for his work identifying the HER2/neu oncogene that is amplified in 25-33% of breast cancer patients and the resulting treatment Herceptin.
Onc is a generic placeholder for a given specific oncogene, such as C-jun.
NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif.
In all cases, the disease is idiopathic, but is thought to involve inactivation of tumor suppressor genes (Menin gene in MEN1), or involve gain of function mutations (RET proto-oncogene MEN 2a).
The iRNA targets Bcl2Like12 gene overexpressed in glioblastoma tumors and silences the oncogene.
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.
Myeloproliferative leukemia virus oncogene has been shown to interact with ATXN2L.
A second oncogene called NRAS mutates, reactivating the normal BRAF survival pathway.