Aicardi–Goutières syndrome (AGS) is a congenital immune-mediated neurodevelopmental disorder caused by mutations in the SAMHD1, TREX1, or Ribonuclease H2 (RNASEH2A, RNASEH2B, RNASEH2C) genes.
He shared a Nobel Prize in Chemistry in 1972 (with Christian B. Anfinsen and William Howard Stein, for work done at Rockefeller University on the structure of the enzyme ribonuclease and for contributing to the understanding of the connection between the chemical structure and catalytic activity of the ribonuclease molecule.