His work there led to the 1938 publication of measurements of the relative abundance of the isotopes of uranium, measurements that were used by Fritz Houtermans and Arthur Holmes in the 1940s to estimate the age of the Earth.
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In the late 1890s, Benson was a central figure in the founding the first of the regional companies associated with the North American Phonograph Company called the Chicago Central Phonograph Company, along with Alfred O. Tate and Thomas Lombard.
During the Manhattan Project, Dunning conducted pioneering work at Columbia University on gaseous diffusion to separate uranium isotopes; others working on the project included Booth, Henry A. Boorse, Willard F. Libby, Alfred O. C. Nier, and Francis G. Slack.