However, if Bax and Bak become activated, and Bcl-xL is sequestered away by gatekeeper BH3-only factors (e.g. Bim), causing a pore to form, cytochrome c is released leading to initiation of caspase cascade leading to apoptotic events.
BCL | Bcl-2 | Bcl-xL | Bcl-2-interacting killer |
In Oxford, the degree of Bachelor of Civil Law (BCL) is a taught postgraduate degree in English law, occupying a similar position as the Master of Laws (LLM) programmes of other British universities, but specifically for common law degree holders.
In molecular biology, the Bcl-x interacting domain is a protein domain found in BAM, Bim and Bcl2-like protein 11.
Innovationen für 10 Instrumente Manfred Niehaus (viola); Bernd Konrad (bcl,cbcl,sax); Willem van Manen (tb); Michael Sell (tp); Hans Peter Jahn (cello); Theo Jörgensmann (cl); Niebergall (b); Georg Strüber (b); Hidegard Butscher (viol); Frank Köllges (dr), 1980 Köln, Misp records 506
Professor Fidelis Oditah, QC, SAN, LLB (Lagos), MA, BCL, DPhil (Oxon), is an English barrister, an authority on insolvency law, and a prospective Governor of Delta State in Nigeria.
Bourne was the son of the Revd R. B. Bourne and was educated at Eton College and at Christ Church, Oxford (BA 1863, BCL 1866, DCL 1871).
A third member of this family - RHBDD1 - cleaves Bcl-2-interacting killer (BIK) - a proapoptotic member of the B cell lymphoma 2 (Bcl-2) family.
Graduating BA in 1842, he took his BCL, was elected Vinerian scholar and fellow, and having read in chambers with Roundell Palmer (afterwards Lord Selborne), was called to the bar at Lincoln's Inn in 1846.
He went to University College, Oxford (University of Oxford), where he was awarded a BA Honours (MA) degree in Modern History, the B.Litt., and the BCL.
When the inhibition of these is lifted, they result in the translocation of Bax and activation of mitochondrial dysfunction resulting in release of mitochondrial apoptogenic proteins cytochrome c, SMAC, and apoptosis-inducing factor (AIF) leading to caspase activation and cell death.
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Biochemical studies have shown that PUMA interacts with antiapoptotic Bcl-2 family members such as Bcl-xL, Bcl-2, Mcl-1, Bcl-w, and A1, inhibiting their interaction with the proapoptotic molecules, Bax and Bak.