In 1957, he joined the CEA laboratory.
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After eight productive years at Oxford, Halban was invited back to France in 1954 by the Prime Minister, Pierre Mendès-France, to direct the building of a nuclear research laboratory at Saclay, outside Paris, which greatly expanded the French Commissariat à l'énergie atomique (Atomic Energy Commission).
His first group was in Biomolecular Simulation at the Commissariat à l'énergie atomique (CEA) at Saclay, France (1989–1998).
The Tokamak de Fontenay-aux-Roses (TFR) was the first French tokamak, built in a research centre of the French Atomic Energy Commission (CEA) in Fontenay-aux-Roses, a commune in the southwestern suburbs of Paris, France.
Tore Supra is situated at the nuclear research center of Cadarache, Bouches-du-Rhône in Provence, one of the sites of the Commissariat à l'Énergie Atomique.
He has served as a visiting scientist at the European Molecular Biology Laboratory, and the Commissariat à l'énergie atomique et aux énergies alternatives, France.
He is a member of the international scientific council of ArcelorMittal and the Commissariat à l'énergie atomique, and a scientific advisor to Rio Tinto Alcan, EDF and ONERA.
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On September 19, 2012, he is named to the position of High Commissioner for Atomic Energy and Alternative Energies by the Council of Ministers of the French Republic, succeeding Catherine Cesarsky.