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News of the deal infuriated the Nasrid ruler Muhammad II al-Faqih of Granada, who promptly sought out the support of Alfonso X of Castile and the Abdalwadid ruler Yaghmorassan of Tlemcen to punish the Marinids.
Henry's successor, Isabella and her husband Ferdinand used the Alcázar for one of the first permanent tribunals of the Spanish Inquisition and as a headquarters for their campaign against the Nasrid dynasty in Granada, the last remaining Moorish kingdom in the Iberian Peninsula.
After the successful recapturing of the Throne of Granada from his uncle, the Sultan Muhammed X in 1447, Muhammed IX continued his bellicose policies with regards to the Kingdom of Castile.