X-Nico

3 unusual facts about Enzyme inhibition


Guanosine pentaphosphate

(p)ppGpp, guanosine pentaphosphate or tetraphosphate is an alarmone which is involved in the stringent response in bacteria, causing the inhibition of RNA synthesis when there is a shortage of amino acids present.

Paraspeckle

The localization patterns were also duplicated in experiments using transcription inhibiting drugs.

Reverse-transcriptase inhibitor

RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses.


Aromatic L-amino acid decarboxylase inhibitor

An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).

Halomon

Recent research has shown that halomon and a related halogenated monoterpene are inhibitors of the enzyme DNA methyltransferase, suggesting a possible mechanism of action for the pharmacological effects.

Kynapcin

Like polyozellin, it inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease.

NLRP10

NLRP8 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.

Polyozellin

It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease.


see also