Within the cell, the intracellular domain of integrin binds to the cytoskeleton via adapter proteins such as talin, α-actinin, filamin and vinculin.
RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes.
Focal length | Focal plane array | Focal infection theory | Adhesion | 35 mm equivalent focal length | List of steepest gradients on adhesion railways | Focal Press | focal plane array (FPA) | focal length | Focal adhesion | focal adhesion |
Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho.
A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.