X-Nico

2 unusual facts about focal adhesion


Focal adhesion

Within the cell, the intracellular domain of integrin binds to the cytoskeleton via adapter proteins such as talin, α-actinin, filamin and vinculin.

RSU1

RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes.


Cytotoxic necrotising factor family

Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho.


see also

PIP5K1C

A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.