This was the sixth and last time that Peter Cushing portrayed the role of the obsessively driven Baron Frankenstein, a part he originated in 1957's The Curse of Frankenstein.
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Since Frankenstein's hands were badly burned in the name of science (possibly in The Evil of Frankenstein or Frankenstein Must Be Destroyed), the shabby stitch-work was done by Sarah (Madeline Smith), a beautiful mute girl who assists the surgeon, and who is nicknamed "Angel".
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The aged Baron Victor Frankenstein (Cushing) is housed at an insane asylum where he has been made a surgeon at the asylum, and has a number of privileges, as he holds secret information on Adolf Klauss, the asylum's corrupt and perverted director (John Stratton).
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David Prowse makes his second appearance as a Frankenstein laboratory creation in this film, his first having been in The Horror of Frankenstein.
Prowse has the distinction of being the only actor to have portrayed Frankenstein's monster in more than one Hammer film: this production marked his first such appearance; the second occasion was 1974's Frankenstein and the Monster from Hell, where his overall appearance was much more horrifically elaborate.
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