This film, therefore, is both the fifth in the series of films based upon Mary Shelley's Frankenstein, directly after The Ghost of Frankenstein, and a sequel to The Wolf Man.
Although Glenn Strange appears as the Monster in most of the film, footage of Chaney as the Monster from The Ghost of Frankenstein and Boris Karloff from Bride of Frankenstein was recycled; Karloff appears in a dream sequence.
The memorial takes the form of a giant filmstrip, the illuminated cut metal panels illustrating scenes from some of his best-known roles, which include The Hunchback of Notre Dame, Things to Come, and The Ghost of Frankenstein.
Ludwig Frankenstein (Cedric Hardwicke) is a doctor who, along with his assistants Dr. Kettering (Barton Yarborough) and Dr. Theodore Bohmer (Lionel Atwill), has a successful practice in Vasaria.
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Despite having been apparently killed at the end of Son of Frankenstein, Ygor was revealed only to have been "maimed by the bullets shot into him by Wolf Frankenstein".
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The footage of the Monster scrambling to escape the fire was later reused at the end of House of Dracula even though Glenn Strange plays the Monster in that film.
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Beginning with the next film, Frankenstein Meets the Wolf Man (in which Lugosi plays the Monster with Chaney switching to his Wolf Man character), and continuing for the rest of the Universal cycle, Frankenstein's Monster would be part of an ensemble cast of creatures.
Wolf was later mentioned in The Ghost of Frankenstein where Ludwig had heard about his brother's encounter with the monster.
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