Sisson was elected as a Democrat to the 73rd and 74th Congresses, holding office from March 4, 1933 to January 3, 1937.
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He was sheriff's attorney in 1913 and corporation counsel for the city of Utica in 1914; in 1922 he was an unsuccessful candidate for election to the 68th United States Congress and in 1928 to the 71st United States Congress.
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He was an unsuccessful candidate for reelection in 1936 to the 75th Congress and continued the practice of law in Utica and Washington, D.C. until his retirement in 1945.
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