Remembered for his extensive research of Ancylostoma duodenale (hookworm), in 1880 he determined that hookworm was the cause of anemia being suffered by workmen building the St. Gotthard railway tunnel.
What was originally considered the main line continues down the valley of the Ticino, crossing the Italian border and continuing to meet the Italian railway system at Pino on the eastern shore of Lake Maggiore.
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Bironico is served by the nearby Rivera-Bironico station, on the Gotthard railway.
The station is on the Swiss Federal Railways Gotthard railway, between Lugano and Chiasso, and is also the junction for the Mendrisio–Stabio railway, currently only used for freight traffic, but being rebuilt as an international connection to Varese.
Rivera is served by the nearby Rivera-Bironico station, on the Gotthard railway.
Intended to provide experience with electric traction, the locomotive was intended, along with Be 4/6 12301, Be 4/6 12302 and Gotthardbahn (Gotthard railway).
For gaining experience for ordering electrical locomotives this locomotive should – as her three sisters Be 3/5 12201, Be 4/6 12302 and Gotthardbahn (Gotthard railway).
For gaining experience for ordering electrical locomotives this locomotive should – as her three sisters Be 3/5 12201, Be 4/6 12301 and Be 4/6 12302 – have been used for services on the Gotthardbahn (Gotthard railway).
Between 1871 to 1875, the SCB and the NOB jointly built the Bötzberg Railway from Pratteln to Brugg and from 1873 to 1882 they extended their joint line to the Gotthard Railway as the Aargauische Südbahn from Rupperswil and Brugg to Immensee.
At Flüelen station, passengers transfer to an SBB train, which takes the Gotthard line up the Reuss Valley and through the Gotthard Tunnel.
From 1907, Castione-Arbedo station was the principal interchange point between the Gotthard railway and the Bellinzona–Mesocco railway (BM), a metre gauge railway linking Bellinzona and various communities in the Val Mesolcina as far as Mesocco.
To the south of Giubiasco station, the Gotthard railway's main line commences its climb over the Monte Ceneri Pass, leaving the valley of the Ticino river that it has followed since it left the Gotthard Tunnel, and heading for Lake Lugano.