X-Nico

39 unusual facts about International Nonproprietary Name


Aflibercept

Aflibercept (INN, USAN) is a fusion protein approved in the United States and Europe for the treatment of wet macular degeneration under the trade name Eylea, and for metastatic colorectal cancer as Zaltrap.

Batimastat

Batimastat (INN/USAN, codenamed BB-94) is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.

Cinacalcet

Cinacalcet (INN) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.

Cipemastat

Cipemastat (rINN, also known as Ro 32-3555 and by the tentative trade name Trocade) is a selective inhibitor of matrix metalloproteinase-1 that has been investigated as an anti-arthritis agent.

Duligotumab

Duligotumab (INN) is a human monoclonal antibody designed for the treatment of cancer.

Enocitabine

Enocitabine (INN, marketed under the brand name Sunrabin) is a nucleoside analog used as chemotherapy.

Enviomycin

Enviomycin (INN, also called tuberactinomycin N) is an antibiotic drug, isolated from Streptomyces griseoverticillatus var.

Etidronic acid

Etidronic acid (INN) or 1-hydroxyethane 1,1-diphosphonic acid (HEDP) is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.

Florantyrone

Florantyrone (INN; also known as Fluorantyrone) is a drug used in the treatment of biliary dyskinesia.

Futuximab

Futuximab (INN) is a chimeric monoclonal antibody designed for the treatment of cancer.

Gitoformate

Gitoformate (INN, or pentaformylgitoxin, trade name Dynocard) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat).

Humanized antibody

The International Nonproprietary Names of humanized antibodies end in -zumab, as in omalizumab (see Nomenclature of monoclonal antibodies).

Ibandronic acid

Ibandronic acid (INN) or ibandronate sodium (USAN), marketed under the trade names Boniva® in the USA, Bondronat® in Europe, Bonviva® in Asia, and ADRONiL by Searle in Pakistan.

Imgatuzumab

Imgatuzumab (INN) is a humanized monoclonal antibody designed for the treatment of cancer.

Isoprenaline

Isoprenaline (INN) or isoproterenol (USAN, trade names Medihaler-Iso and Isuprel) is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma.

Itolizumab

Itolizumab (INN, trade name Alzumab) is a ‘first in class’ humanized IgG1 monoclonal antibody developed by Biocon.

Lampalizumab

Lampalizumab (INN) is a humanized monoclonal antibody designed for the treatment of geographic atrophy secondary to age-related macular degeneration.

Lebrikizumab

Lebrikizumab (INN) is a humanized monoclonal antibody and an experimental immunosuppresive drug for the treatment of asthma that cannot be adequately controlled with inhalable glucocorticoids.

Ligelizumab

Ligelizumab (INN) is a humanized monoclonal antibody that binds to IGHE.

Methylthioninium chloride

Methylthioninium chloride (INN, or methylene blue, proposed trade name Rember) is an investigational drug being developed by the University of Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau protein aggregation.

Monomethyl auristatin E

In International Nonproprietary Names for MMAE-MAB-conjugates, MMAE is referred to as vedotin.

Norfenefrine

Norfenefrine (INN; brand names Coritat, Energona, Hypolind, and Novadral), also known as m-octopamine (or 3-octopamine) and 3,β-dihydroxyphenethylamine, is an adrenergic agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico.

Omecamtiv mecarbil

Omecamtiv mecarbil (INN), previously codenamed CK-1827452, is a cardiac specific myosin activator.

Orticumab

Orticumab (INN) is a human monoclonal antibody that is used as an anti-inflammatory agent and binds to oxLDL.

Pamidronic acid

Pamidronic acid (INN) or pamidronate disodium (USAN), pamidronate disodium pentahydrate is a nitrogen containing bisphosphonate, used to prevent osteoporosis.

Panitumumab

Panitumumab (INN), formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans).

Parsatuzumab

Parsatuzumab (INN) is a humanized monoclonal antibody designed for the treatment of cancer.

Patritumab

Patritumab (INN) is a human monoclonal designed for the treatment of cancer.

Pentylenetetrazol

Pentylenetetrazol (INN), also known as pentylenetetrazole, metrazol, pentetrazol, pentamethylenetetrazol, Cardiazol or PTZ, was a drug used as a circulatory and respiratory stimulant.

Perakizumab

Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis.

Plicamycin

Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus.

Quilizumab

Quilizumab (INN) is a humanized monoclonal antibody designed for the treatment of asthma.

Siltuximab

Siltuximab (INN) (also known as CNTO 328, Anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins) monoclonal antibody.

Simtuzumab

Simtuzumab (INN; formerly GS 6624) is a humanized monoclonal antibody designed for the treatment of fibrosis.

Sivelestat

Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.

Solitomab

Solitomab (INN) is a mouse monoclonal antibody designed for the treatment of cancer.

Sri Lanka National Pharmaceuticals Policy

In Sri Lanka, the Ministry of Health requested Prof. Seneka Bibile to look into his matter and he prepared the Ceylon Hospital Formulary (CHF) of about 630 drugs under their generic names.

Tocofersolan

Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E.

Zatuximab

Zatuximab (INN) is a chimeric monoclonal antibody designed for the treatment of cancer.


Benznidazole

Benznidazole (INN, formerly marketed by Hoffman-La Roche under the trade names Rochagan and Radanil) is an antiparasitic medication used in the treatment of Chagas disease.

Levomefolic acid

Levomefolic acid (INN) (also known as 5-MTHF, l-methylfolate and 5-methyltetrahydrofolate) is the active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.