Interstate 75 | Interstate 90 | Interstate 5 | Interstate 94 | Interstate 81 | Interstate 80 | Interstate 70 | Interstate 40 | Interstate 95 | Interstate 10 | Interstate 65 | Interstate 64 | Interstate 44 | Interstate 90 in Minnesota | Interstate 71 | Interstate 35 | Interstate 15 | Interstate 476 | Interstate 78 | Interstate Highway System | Interstate 85 | Interstate 74 | Interstate 294 | Interstate 20 | Interstate Commerce Commission | Interstate 87 | Interstate 55 | Interstate 471 | Interstate 287 | Interstate matches in Australian rules football |
Interstate 480 cuts through the extreme northeast corner of the city, and Interstate 80, the Ohio Turnpike, bisects the city from west to east.