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It is adjacent to the Capital City Airport and a short distance east of the Harrisburg West Shore interchange of the Pennsylvania Turnpike (Interstate 76, which forms the southern boundary of the base) with Interstate 83.
In Highspire, it intersects Eisenhower Boulevard, a main road connecting PA 230 to Interstate 283, Pennsylvania Route 283, and Interstate 76 (Pennsylvania Turnpike).
The Pennsylvania Turnpike (Interstate 76) crosses Sideling Hill east of Breezewood, Pennsylvania, bypassing the two-lane Sideling Hill tunnel and the nearby Rays Hill tunnel that were formerly used by the Turnpike.