During the X-Cutioner's Song crossover, the villain Stryfe gave Mister Sinister a canister that he claimed contained 2,000 years worth of genetic material from the Summers bloodline.
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The instant cure gave Magneto a vast army overnight and allowed him to begin carrying out his plans for world conquest in the Eve of Destruction crossover.
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In the video game Marvel: Ultimate Alliance, a side mission includes saving a S.H.I.E.L.D. Omega Base Computer (which contains research data on the Legacy Virus) from being destroyed by 3 out of 5 Super Soldiers.
During the course of the adventure the player will need to make decisions (such as choosing whether to save Nightcrawler or Jean Grey) or complete certain tasks (like stopping a group of mutated soldiers from destroying a computer that holds research on the Legacy Virus).
virus | Tron: Legacy | West Nile virus | Subaru Legacy | Safe, Accountable, Flexible, Efficient Transportation Equity Act: A Legacy for Users | Legacy | RNA virus | Legacy Recordings | Legacy of a Quiet Man | Herpes simplex virus | computer virus | TRON: Legacy | Human T-lymphotropic virus | Computer virus | Volcanic Legacy Scenic Byway | Virus | Legacy system | Influenza A virus subtype H1N1 | Herpes Simplex Virus | Ebola virus | Virus Buster Serge | Vesicular stomatitis virus | varicella zoster virus | Uganda Virus Research Institute | Tupac Shakur Legacy | Tobacco Mosaic Virus | Sin Nombre virus | Ross River virus | Porcine reproductive and respiratory syndrome virus | My Uncle's Legacy |