Leo Gorcey's wife, Kay Marvis, has a supporting role as Irma Treadwell.
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After an afternoon of playing baseball, Muggs McGinnis (Leo Gorcey) and the East Side Kids gang arrive at the door of their clubhouse, where a man named Higgins (silent comedian Harry Langdon, in one of his last film appearances) is removing their "East Side Club" sign.
Leo Gorcey's father, Bernard, appears as Mr. Johnson, the taxi driver.
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Deciding to cover the murder for the absent Jim, Muggs McGinnis (Leo Gorcey), who is working as a copy boy on the paper, asks Glimpy (Huntz Hall) to drive him to the Wilson house in the paper's delivery car.
While pals Skinny (Donald Haines), Danny Graham (Bobby Jordan), Peewee (David Gorcey), Algy Reynolds (Eugene Francis), and Scruno (Sunshine Sammy Morrison) all work at the Reynolds Aviation Company, which is run by Algy's father (Herbert Rawlinson), Muggs (Leo Gorcey), the only one of the kids who refuses to work, spends his time flirting with an ambulance nurse named Helen (Joan Barclay).
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The scene in which the car flips onto its side was not scripted; Leo Gorcey was driving the car, and had made the turn too fast.
Slip (Leo Gorcey) goes with him down to the detective's office to demand payment, but finds the office empty.
Leo Gorcey's father, Bernard, has a cameo as a telegram messenger.
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In the East Side Kids' clubhouse, Muggs McGinnis (Leo Gorcey) laments the epidemic of mugging that has been plaguing their streets.
In New York, the East Side youth gang, consisting of Muggs McGinnis (Leo Gorcey), Danny Collins (Bobby Jordan), Glimpy Stone (Huntz Hall), Scruno (Ernest Morrison), Skinny (Bill Lawrence), and Peewee (David Gorcey), are falsely arrested on the wharf because the truck they are playing in was stolen.
He summons his old friend, Colonel Mitchell Reiker (John Litel) to ask him if he will care for his son Slip (Leo Gorcey) when he dies.
When Muggs (Leo Gorcey) refuses to train for the Golden Gloves match unless he has his own private camp in the country, Danny (Bobby Jordan) placates his pal by enlisting members of the Vassey Street Boys' Club in the Conservation Corps.
Leo Tolstoy | Pope Leo XIII | Leo Gorcey | Leo Burnett | Leo Brouwer | Leo VI the Wise | Leo | Pope Leo X | Leo Durocher | Wadada Leo Smith | Ted Leo | Pope Leo I | Pope Leo IX | Melissa Leo | Leo Carrillo | Ted Leo and the Pharmacists | Leo Castelli | Leo Burnett Worldwide | San Leo | Leo Strauss | Leo Marks | Leo Laporte | Léo Ferré | Leó Szilárd | Leo Slezak | Leo Frobenius | Leo Cárdenas | Pope Leo XII | Leonardo Leo | Leo Fall |
After completing the pilot film for the series, producer Sam Katzman was able to convince former Dead End Kids Bobby Jordan and Leo Gorcey to join the series.
After completing this film, Bobby Jordan left the Universal Dead End Kids/Little Tough Guys series, and signed on to Monogram Pictures to costar with fellow Dead End Kid Leo Gorcey in the East Side Kids series.
Leo Gorcey would later adopt this as his character middle name in the The Bowery Boys films.