As originally built, the road was earlier known as "Military Highway", a name it shared with another roadway in South Hampton Roads which was built beginning in 1943.
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Mercury Boulevard is a major north-south commercial corridor in the region, and intersects Interstate 64 in an elaborate interchange with flyovers in Hampton near the Hampton Coliseum.
Mercury Records | Mercury | Wilshire Boulevard | Sunset Boulevard | Mercury (planet) | Project Mercury | San Jose Mercury News | Mercury Rev | Roxas Boulevard | Mercury (mythology) | Mercury Theatre | mercury | Freddie Mercury | mercury (element) | Hollywood Boulevard | Mercury Prize | Junipero Serra Boulevard | Sunset Boulevard (musical) | Pico Boulevard | Octavia Boulevard | MacArthur Boulevard | Phoenix Mercury | Mercury Seven | Man o' War Boulevard | Boulevard des Allumettières | San Vicente Boulevard | Mercury Cougar | London Mercury | Geary Boulevard | Boulevard des Allumettières (Gatineau) |
U.S. Route 258, later known as Mercury Boulevard in honor of the astronauts of Project Mercury at NASA's center at nearby Langley Air Force Base, led from Fort Monroe to the James River Bridge and has been a major traffic artery in the area for many years.