According to Nevermind producer Butch Vig on the Classic Albums: Nirvana - Nevermind DVD, "Drain You" had more guitar overdubs than any other song on the album: one clean track and five distorted tracks; two tracks of the Mesa Boogie, two tracks of the Fender Bassman, and one that they called the "Super Grunge" track.
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This market was dominated by companies such as Marshall and Mesa Boogie—both of which had gotten started modifying Fender amps (the Bassman and the Princeton, respectively).
Amp-wise, he has previously used Mesa Boogie Bass 400+ amplifiers with Mesa Boogie 4x10 and 2x15 cabinets, as well as Ampeg SVT amplifiers and cabinets.