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3 unusual facts about Microscopy


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The technology is applied in Beam Shaping, Astronomy, Vision Science, retinal imaging, general Microscopyand supports national defense; any application in need of wavefront manipulation.

Microtome

Electron Microscopy Technique: after embedding tissues in epoxy resin, a microtome equipped with a glass or gem grade diamond knife is used to cut very thin sections (typically 60 to 100 nanometer).

These extremely thin cuts are important for use with transmission electron microscope (TEM) and Serial Block-Face Scanning Electron Microscopy (SBFSEM), and are sometimes also important for light-optical microscopy.


Archibald Howie

In 1965, with Hirsch, Whelan, Pashley and Nicholson, he published the seminal text Electron Microscopy of Thin Crystals.

Arthur Farre

He contributed papers on microscopy to the Royal Microscopical Society's Journal and Transactions, and was president of the society in 1851–2.

Athlete's foot

Athlete's foot can usually be diagnosed by visual inspection of the skin, but if the diagnosis is uncertain, direct microscopy of a potassium hydroxide preparation of a skin scraping (known as a KOH test) can confirm the diagnosis of Athlete's foot and help rule out other possible causes, such as candidiasis, pitted keratolysis, erythrasma, contact dermatitis, eczema, or psoriasis.

Beth Israel Deaconess Medical Center

James B. Aguayo-Martel MD MPH, developer of MR microscopy and deuterium spectroscopy.

Crystallographic image processing

Crystallographic image processing (CIP) is a set of methods for determining the atomic structure of crystalline matter from high-resolution electron microscopy (HREM) images obtained in a transmission electron microscope (TEM).

Delbert Philpott

At the University of Illinois Medical School in Chicago he established the first electron microscope facility, before moving to the Marine Biological Lab and Institute for Muscle Research in Woods Hole, MA in 1952, where he was Head of Electron Microscopy, directing research projects under Nobel Laureate Albert Szent-Györgyi in the winter and for the Marine Biological Lab at Woods Hole during the summer.

Diagnostic electron microscopy

The transmission electron microscope (TEM) is used as an important diagnostic tool to screen human tissues at high magnification (the ultrastructural level), often in conjunction with other methods, particularly light microscopy and immunofluorescence techniques.

Differential interference contrast microscopy

Differential interference contrast (DIC) microscopy, also known as Nomarski Interference Contrast (NIC) or Nomarski microscopy, is an optical microscopy illumination technique used to enhance the contrast in unstained, transparent samples.

Erik Enby

His analyses are based on blood microscopy work carried out by the professor in zoology, Günther Enderlein, towards the end of his life.

Ernst Ruska-Centre

The Ernst Ruska-Centre (ER-C) for Microscopy and Spectroscopy with Electrons is a German research establishment conjointly operated by the Jülich Research Centre and RWTH Aachen University on a pari passu basis.

Gunshot residue

In the latest ASTM Standard Guide for GSR analysis by Scanning Electron Microscopy/Energy Dispersive X-ray Spectrometry (SEM-EDX) particles containing lead, antimony and barium, and respecting some rules related to the morphology and to the presence of other elements are considered characteristic of GSR.

History of water filters

Fathers of microscopy, Antonie van Leeuwenhoek and Robert Hooke, used the newly invented microscope to observe for the first time small material particles that lay suspended in the water, laying the groundwork for the future understanding of waterborne pathogens.

Institute of Molecular Biotechnology

The Electron Microscopy facility provides two transmission electron microscopes of 100 kV and 300 kV.

Lennart Nilsson

When he was approximately fifteen, he saw a documentary about Louis Pasteur that made him interested in microscopy.

Mark Welland

Welland moved to Cambridge in 1987 and set up the first tunneling microscopy group in the UK in collaboration with John Pethica.

Photosynthetic picoplankton

In 1988, two American researchers, Carpenter and Chang, had suggested estimating the speed of cell division of phytoplankton by following the course of DNA replication by microscopy.

Plasmonic lens

Its intended uses are focusing, imaging, light beam shaping, subwavelength optics, subwavelength light wave guiding, novel optical and magneto-optic data storage, light generation, microscopy, biophotonics, biological molecule sensors, and solar cells, as well as other applications.

Single-molecule FRET

Fluorescence signal is detected either using ultra sensitive CCD or CMOS cameras for wide field microscopy or avalanche photodiodes for confocal microscopy.

Skip Palenik

He is most famous for providing trace evidence analysis and forensic microscopy for many high-profile cases including the Oklahoma City Bombing, Unabomber investigation, Hillside Strangler investigation and the JonBenet Ramsey case, and for his contributions to books and television programs including TruTV's Forensic Files (to which he is a frequent contributor).

Solid-state nuclear magnetic resonance

Membrane proteins and amyloid fibrils, the latter related to Alzheimer's disease and Parkinson's disease, are two examples of application where solid-state NMR spectroscopy complements solution-state NMR spectroscopy and beam diffraction methods (e.g. X-ray crystallography, electron microscopy).

Surface plasmon resonance

This method provides a high contrast of the images based on the adsorbed amount of molecules, somewhat similar to Brewster angle microscopy (this latter is most commonly used together with a Langmuir–Blodgett trough).

Vertico SMI

The Vertico-SMI microscope was developed by Christoph Cremer, Professor of Applied Optics and Information Processing at Heidelberg University and is based on the combination of light optical techniques of localization microscopy (SPDM, Spectral Precision Distance Microscopy) and structured illumination (SMI, Spatially Modulated Illumination).


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