Mister Fantastic reprograms Galactus' ship to take him to the Negative Zone, where he will apparently have an abundance of worlds to consume.
During a mission in the Negative Zone to give it life, one of their ships suffered a freak collision from a meteor, causing it to crash-land on the nearby world of Arthoros.
With her new position, she allowed the Avengers to disband and be replaced by her 'Americommandos', who arrested the X-Men and other mutants, captured 'illegal' superhumans like Luke Cage and Spider-Man, and arranged for the Fantastic Four to be lost in the Negative Zone, forcing Henry Pym, the Invisible Woman, and the Wasp into retirement, and 'killing' Tony Stark while he was undergoing heart surgery while keeping his brain alive to use his intellect.
At one point, Dragon Man had been placed in the Negative Zone, and like most of the other prisoners, was conscripted into service when Blastaar attacked the prison.
In the first series, it was revealed that "Big Brain" is a drone controlled from the Negative Zone, where Sue Storm is held in a kind of stasis.
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Reed Richards, Mr. Fantastic - Formerly the Big Brain robot, Reed has recently returned from repairing a hole in the Negative Zone caused by Hyperstorm.
The Super Skrull, posing as She-Hulk, penetrates Reed's defenses and in the midst of his attack transports himself and Reed into the Negative Zone where they encounter Annihilus.
Initially, he only uses the Nega-Bands for flight, energy siphoning, energy blasts, and transportation to and from the Negative Zone.
It is revealed in the Guardians of the Galaxy series that Nagan is one of the inmates left behind in the Negative Zone's Prison 42 and was used to help Star-Lord communicate with Mantis telepathically to bring the other Guardians to help defend the 42 prison against Blastaar and his horde from invading Earth via the non-functional portal there.
During his time with the Guardians of the Galaxy Groot took part in all of the team's missions, taking on threats like the Badoon, Blastaar, the Negative Zone forces, The Shi'Ar, The Magus and The Cancerverse.
Although an alien pirate mysteriously died in H.E.R.B.I.E.'s presence, and the villain Blastaar suddenly escaped from the Negative Zone, nobody suspects that H.E.R.B.I.E. was responsible.
Janus plotted to siphon the power of the Negative Zone, however he was apparently destroyed this time by an energy disruption.
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He clashed with the Fantastic Four and developed a module capable of harnessing anti-matter energy, and attempted to cross into the Negative Zone to gain more power.
In the Marvel Universe, Jump Gates are used by the United States Government to connect each state superhero team of the Fifty State Initiative with the Negative Zone's Prison 42 and in turn the other states Jump Gates.
Following the Onslaught saga, Kristoff and Nathaniel tried to collect the now-missing FF's equipment located in the Negative Zone.
The Fantastic Four captured Mahkizmo and transferred him to the newly constructed Vault in the Negative Zone.
Plot: Three years prior to the story Dr. Banner discovered the Negative Zone, a dimension which contains vast amounts of energy, and was tricked by the terrorist organization HYDRA into building "the Energy Well", a means of harvesting this energy, to power their weapon of mass destruction.
He was one of the first villains imprisoned in the Negative Zone prison.
The fight against Onslaught would lead to the Baxter Building where Rikki sacrificed herself to push Onslaught into the Negative Zone.
Mar-Vell tricks the Adaptoid into copying his nega-bands, which act as a portal to the alternate dimension the Negative Zone.
While back at the Baxter Building, Reed tests out his newest invention: A portal to the Negative Zone.
Despite Fury's orders, Reed sends five probes into other dimensions, including the N-Zone.
However, she is in the process of being transported to the Negative Zone, while deep inside the Baxter Building.
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