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unusual facts about Niemann-Pick disease, type C



Christoph Niemann

Christoph Niemann (born 1970 in Waiblingen, West Germany) is an illustrator, graphic designer, and (co-)author of several books including some children's books.

Cyclodextrin

In 2009, research from the lab of Michael S. Brown and Joseph L. Goldstein, Nobel Prize winning scientists who pioneered the study of cholesterol metabolism, was published showing how cyclodextrin assists in moving cholesterol out of lysosomes in Niemann-Pick type C disease.

ML domain

Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol.

Myelin regulatory factor

Myrf has been shown to be significantly downregulated in a mouse model carrying the same mutation in the NPC1 protein that is underlying Niemann-Pick type C1 disease, a neurodegenerative process in which dysmyelination is a main pathogenic factor.

Niemann Foods

Niemann Foods (NFI) is a company headquartered in Quincy, Illinois that owns and operates over 100 supermarkets, convenience, pet and hardware stores mostly under the County Market, County Market Express, Cub Foods, ACE Hardware, Pet Supplies Plus, Pick-A-Dilly and Save-A-Lot banners in Illinois, Iowa, and Missouri.

Roscoe Brady

Dr. Brady and his colleagues identified the enzymatic defects in Gaucher disease (3.4), Niemann-Pick disease (5), Fabry disease (6) and the specific metabolic abnormality in Tay-Sachs disease (7,8).

What Do You Want

Niemann wrote it with Richie Brown and Rachel Bradshaw, the daughter of National Football League quarterback Terry Bradshaw, who also sings a backing vocal on it.


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