The first references to Águas Santas are found in a document dating from the year 1120, where Pope Callixtus II mentions the monastery of Aquis Sanctis.
The altar structure of the chapel was formally consecrated in 1123 by Pope Callixtus II.
An embassy of three cardinals was sent by Calixtus II to Germany, and negotiations for a permanent settlement of the investiture struggle were begun in October 1121 at Würzburg, where it was agreed that a general truce should be proclaimed in Germany, that the Church should have free use of its possessions, and that the lands of those in rebellion should be restored.
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Calixtus II devoted his last few years to re-establishing Papal control over the Campagna and establishing the primacy of his See of Vienne over the See of Arles, an ancient conflict.
This name, romanised as "Rezoa", appears first in October 1119 in a document from Pope Callixtus II.
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Reginald II, Count Palatine of Burgundy and Count of Mâcon, Vienne and Oltingen, was born in 1061; he was the eldest son of William I of Burgundy and brother to Stephen I of Burgundy, his successor, as well as to Pope Callixtus II.