It is recorded that the parishioners of Bellerby and Skeltoncote sent a petition to the Pope in Rome in 1474 (Pope Sixtus IV), asking him to sponsor the use of a chapel in Bellerby for Mass and the appointment by the Rector of Spennithorne of a priest to serve the Chapel, and provided him with a home in Bellerby.
In 1475 and 1488, Dorothea visited the reigning popes (Sixtus IV and Innocent VIII) in Rome and her sister Barbara in Mantua.
In 1450 his father had received license to erect an oratory at the manor house, and in 1474 his elder brother, Thomas Clopton, obtained permission from Pope Sixtus IV to add a chapel to the house for the celebration of divine service.
In 1482 Pope Sixtus IV issued a papal bull which granted the village the right to hire a lay priest.
But the guest house had financial problems, so people like Pope Sixtus IV donated money.
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The bull Aeterni regis of 1481, delivered by Pope Sixtus IV, had confirmed the substance of the Treaty of Alcáçovas, which itself had confirmed Castile in its possession of the Canary Islands and had granted to Portugal all further new lands to be won by Christendom in Africa and the East Indies.
In the controversy with the Orsinis, he was accused of treason by Pope Sixtus IV and was held in Castel Sant'Angelo together with Cardinal Giovanni Colonna.
Herbarium Apuleii Platonici depicts 131 plants with their synonymy and instructions for their use in medicines and was first published in 1481 at Monte Cassino near Rome by Johannes Philippus de Lignamine, a Sicilian courtier and physician to Pope Sixtus IV.
On 23 June 1482, Pope Sixtus IV decreed an interdict against the Republic of Venice, unless it abandoned within 15 days its siege of Ferrara.
“ The portrait of the queen is placed in the Vatican, The Sistine Chapel, on the Roselli’s diptych named „Speech at the hill“ right next to the Pope Sixtus IV, in the company of the captains, the maids of honor and her son.
Local tradition had always maintained that Okkenhaug Chapel had once belonged to a monastery; for centuries historians dismissed this, until in 1906 a letter dated 1475 from Pope Sixtus IV to Abbot Stephen of Trugge was discovered in the Vatican archives referring to the request for the restoration of the site as a functioning monastery.
These now focused on a single institution, the original and by this time extremely large Arcispedale di Santo Spirito in Sassia, the buildings of which dated from the time of Pope Sixtus IV (1471–84), which at its height was capable of accommodating over 1,000 patients, with additional spaces for contagious and for dangerously insane cases, and more than 100 medical staff, and an international remit.