As a bookseller and apprentice printer he established a network of Italian connections that helped him act as a go between and publisher of Italian reformed thinkers and writers, such as Vermigli, Pier Paolo Vergerio, Jacopo Aconcio, Bernardino Ochino, Lelio Sozzini, Sebastian Castellio, Celio Secondo Curione, etc.
Having been educated at the age of twenty at the University of Lyon, Castellio was fluent in both French and Italian, and became an expert in Latin, Hebrew and Greek as well.
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Calvin, upon returning to Geneva, asked Castellio to join him in 1542 as Rector of the Collège de Genève.
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