Southeast Guilford High School is located in the southeast Guilford County, off U.S. Route 421.
US 421 begins at Fort Fisher and heads through North Carolina's southeastern beaches to Wilmington.
U.S. Highway 421 and Ocean Boulevard are the major roads through the area.
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
After US 25 breaks away and goes north toward the Blue Grass Army Depot, KY 21 continues to the east and intersects US 421 in Bighill before ending at the Jackson County line.