32 law officials were sent to Hattiesburg to assist with traffic control near the intersection with I-59 and U.S. Route 49.
"The Crossroads", an intersection of U.S. Route 61 and U.S. Route 49 in Clarksdale, Mississippi, where Robert Johnson supposedly sold his soul to the Devil
Continuing on 49 brings one to the cloverleaf interchange at U.S. Route 11, one of very few in the South to lack merging lanes between loop ramps, thus altering the usual weaving patterns which plague many of these interchanges.
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U.S. 49 passes Hattiesburg's primary medical facility, Forrest General Hospital, and the campus of the University of Southern Mississippi before arriving at another, more standard cloverleaf interchange with Interstate 59.
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Various state highway interchanges and junctions are encountered before the route passes near Camp Shelby, then through an interchange with U.S. Route 98 just south of Hattiesburg.
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The highway is also the subject of songs by Big Joe Williams and Howlin' Wolf.
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
Highway 49B turns south onto Columbia Street and runs south out of town past the Allin House, William Nicholas Straub House, Centennial Baptist Church, and the St. Mary's Catholic Church.