US 522 passes through the Ridge and Valley Province of the Appalachian Mountains of central Pennsylvania, connecting Hancock, Maryland on the Potomac River with McConnellsburg, Mount Union, Lewistown, Middleburg, and Selinsgrove on the Susquehanna River.
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
It is located on Route 522, approximately 2 miles to the east of the border of the Shenandoah National Park.
U.S. Route 522 (US 522) is a part of the U.S. Highway System that runs from Powhatan, Virginia to Selinsgrove, Pennsylvania.