What is now US 85 from El Paso, Texas to then-U.S. Route 66 (now SR 6) in Los Lunas, New Mexico (south of Albuquerque) was shown as U.S. Route 466 in an early 1925 plan for the U.S. Highway System.
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
From the New Mexico border, US 80 (concurrent with U.S. Route 85) formerly passed through the Mesilla Valley communities of Anthony, Vinton, and Canutillo.