In the 1980s and before, there were many daily express services from Wetzlar Station to remote destinations such as Oberstdorf.
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A through carriage also gave a direct connection to Ljubljana and Zagreb.
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There is also an hourly Regionalbahn service on the Gießen–Wetzlar–Weilburg–Limburg route, which since the 2011/2012 timetable change has been operated by Hessische Landesbahn.