These substances are AT1-receptor antagonists; that is, they block the activation of Anxiety/aggression-driven depression
Anxiolytic medications that act as 5-HT receptor agonists (in particular, 5-HT1A) together with CRH and/or cortisol antagonists (which are implicated in the stress response) are hypothesized to be an appropriate method of achieving this therapeutic response.
The Brethren of the Free Spirit are the main antagonists of the science fiction trilogy Venus Prime by Arthur C. Clarke & Paul Preuss, in which the members believe that first contact between aliens from Crux and humanity should be with them only.
While making burgers, the player must avoid the antagonists, three types of enemies: Mr. Hot Dog, Mr. Pickle, and Mr. Egg.
Researchers at Ono have discovered a novel series of potent CCR5 small molecule antagonists.
Shinra, one of the antagonists in the RPG Final Fantasy VII could be considered an example of a corporate republic due to its encompassing scope and massive power in planet affairs.
Several antagonists for this receptor have been developed and are widely used in research, with the best-known agents being the selective CRF-1 antagonist antalarmin and a newer drug pexacerfont, although several other ligands for this receptor are used in research, such as LWH-234, CP-154,526, NBI-27914 and R-121,919.
Thus NMDA receptor antagonists including MK-801 have been extensively studied for use in treatment of diseases with excitotoxic components, such as stroke, traumatic brain injury, and neurodegenerative diseases such as Huntington's, Alzheimer's, and amyotrophic lateral sclerosis.
Most recently, it is the name of the antagonists in James A. Owen's 5th addition to the Imaginarium Geographica series.
David Chocarro starred as the main protagonist, with the special participation of Maritza Rodríguez and Elizabeth Gutiérrez, while Saúl Lisazo, Felicia Mercado and Marlene Favela starred as the main antagonists.
Musician and actor Seu Jorge (who played Mané Galinha in City of God) was invited by director José Padilha to act as one of the antagonists, Beirada; Maria Ribeiro is also back as Roseane, who is no longer married to Nascimento, but to a left wing Congressman.
The scene where the song was performed features Justice, disguised as a very ugly girl Louise Nordoff, who comes up on stage to sing and later reveals her true self as a part of a plan to win a bet with the two main antagonists in the episode, Hayley (Jillian Clare) and Tara (Jamie Snow).
In the video game Assassin's Creed IV: Black Flag, Du Casse serves as one of the antagonists, albeit it is an alternate, younger form of him.
Chester and Clyde (Chester y Clyde) (voiced by Héctor Lee and Francisco Colmenero) - A pair of oafish crows who at first were looking to eat Katy and served as minor antagonists.
The antagonists of the series are styled Federalists, or sometimes "Hamiltonians", after the historical political party of George Washington and Alexander Hamilton.
He made an appearance in Ubisoft action-adventure game, Assassin's Creed IV: Black Flag, as one of the main antagonists and a Grand Master of the Templar Order.
In Assassin's Creed: Revelations (2011), Palaiologos plays a central role to the plot as one of the main antagonists.
Grendel is one of three antagonists in the Anglo-Saxon epic poem Beowulf.
NMDAR antagonists fall into four categories: Competitive antagonists, which bind to and block the binding site of the neurotransmitter glutamate; glycine antagonists, which bind to and block the glycine site; noncompetitive antagonists, which inhibit NMDARs by binding to allosteric sites; and uncompetitive antagonists, which block the ion channel by binding to a site within it.
This includes drugs less immediately classed to a slowing of the metabolism such as with GABAergics like GHB or glutamatergic antagonists like PCP or Ketamine.
Padan Fain, one of the primary antagonists of The Wheel of Time fantasy series
Padan Fain is one of the primary antagonists of The Wheel of Time fantasy series by Robert Jordan.
Published in the April 2007 issue of Nature Neuroscience, their brief communication outlined an experiment designed to test the underlying theory proposed to explain the purported efficacy of declarative memory deficits associated with the mouse model of human Down Syndrome.
The Purifiers made only sporadic appearances since their first appearance, but returned to prominence in the 2000s, when they became prominent antagonists in the series New X-Men and X-Force, and played a major role in the 2007 - 2008 crossover storyline X-Men: Messiah Complex.
He was one of the antagonists in the hit South Korean medical drama White Tower, and had a supporting role in the romantic comedy Coffee Prince.
The telenovela was filmed in Miami, Florida and it starred Scarlet Ortiz and Jorge Aravena as the main protagonists while Colombian actress Aura Cristina Geithner and Venezuelan actress Astrid Gruber starred as the main antagonists.
Batman and Robin trace the Archer to his hideout at the Earl of Huntington Archery Range (Robin Hood was the alias of the Earl of Huntingdon) in Gotham's Green Forest section, where Alfred Pennyworth attempts to divert the antagonists long enough for Batman and Robin to inspect his lair.
The main antagonists in the show were the Anthenians, who were modelled on a combination of Ancient Rome and Sparta; their home planet is shown in the episode involving the gladiatorial games.
Another version of the Space Ironmen appears in the movie Kamen Rider Fourze the Movie: Space, Here We Come!, but in a reversal of roles as the main antagonists.
The game's antagonists the Nightsisters were first introduced in the Star Wars story The Courtship of Princess Leia.
The majority of the villagers are of the Pare tribe (legend holds that they moved up the mountains as a security measure in a similar way other villages built forts. Their main antagonists were Maasai warriors who they call 'Kwavi' and Chagga).
The album title is a reference to the Sleestak, the lizard-like antagonists in the 1974 TV series Land of the Lost.
It currently hosts the Jedi Training Academy, where children between the ages of 4 and 12 are randomly chosen to participate in the show to become Jedi padawan and face off Star Wars antagonists.
The game's antagonists are the Coyotes, a group of hitmen recruited to carry out OMAR's scheme by terrorizing commercial installations throughout the region using weaponry stolen from the ultra-secret Site 4 base at Papoose Lake in Nevada.
Some series alternate between using such antagonists and furthering the series' ongoing plotlines (as in Buffy the Vampire Slayer, Fringe and The X-Files, where fandom is often divided over preference for one type of episode versus the other), while others use these one-time foes as pawns of the recurring adversaries (as in Kamen Rider, Super Sentai and their American equivalent, Power Rangers).
Similarly, Karin Son and Shaia Hishizaki were re-used in Angel Blade as minor antagonists.
Yusef appears in Age of Empires II: The Conquerors as one of the primary antagonists in the "El Cid" campaign.
The film has done poorly in Japanese box offices, which may be due to the film's theme of a religious war with the antagonists as analogies of the Happy Science movement in Japan.