X-Nico

unusual facts about apoptosis-inducing factor



Aspergillus ochraceus

Ochratoxin A (OTA), a mycotoxin produced by A. ochraceus, contaminates food and initiates apoptosis of plant cells.

Autocrine signalling

For example, a small-molecule mimetic of Smac/Diablo that counteracts the inhibition of apoptosis has been shown to enhance apoptosis caused by chemotherapeutic drugs through autocrine-secreted tumor necrosis factor alpha (TNFα).

Caspase

H. Robert Horvitz initially established the importance of caspases in apoptosis and found that the ced-3 gene is required for the cell death that took place during the development of the nematode C. elegans.

DFFA

The main function of this domain is the inhibition of DFFB by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process.

Fas receptor

However, two isoforms, the apoptosis-inducing membrane-bound form and the soluble form, are normal products whose production via alternative splicing is regulated by the cytotoxic protein TIA1.

Follicular atresia

TNF-related apoptosis-inducing ligand TRAIL activates Caspase 3 (CASP3), which in turn interacts with caspases 6, 7, 8, 9, and 10 to induce apoptosis in granulosa cells.

Giorgio Stassi

He has recently identified the role of certain cytokines, most importantly of IL-4, to block apoptosis in cancer cells in an autocrine fashion, i.e. the tumor cell itself provides the apoptosis-inhibitory stimulus by production of IL-4.

History of HIV/AIDS

Non-human SIVs contain a nef gene that down-regulates CD3, CD4, and MHC class I expression; most non-human SIVs, therefore, do not induce immunodeficiency; the HIV-1 nef gene, however, has lost its ability to down-regulate CD3, which results in the immune activation and apoptosis that is characteristic of chronic HIV infection.

Howel–Evans syndrome

A third member of this family - RHBDD1 - cleaves Bcl-2-interacting killer (BIK) - a proapoptotic member of the B cell lymphoma 2 (Bcl-2) family.

Hsp90 inhibitor

Mitochondrial Hsp90 is involved in complex signaling pathway that prevents initiation of induced apoptosis.

Hsromega

The hsrω-n transcript directly or indirectly affects the localization/stability/activity of a variety of proteins including hnRNPs, Sxl, Hsp83, cAMP response element binding binding protein (CBP), Drosophila inhibitor of apoptosis protein 1 (DIAP1), JNK-signalling members, proteasome constituents, lamin C, ISWI, HP1 and poly(ADP)-ribose polymerase.

Involucrin

Apigenin, a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent, has been found to regulate normal human keratinocyte differentiation by suppressing involucrin, and this is associated with reduced cell proliferation without apoptosis.

IRF8

IRF8 mediates the expression of Fas, Bax, FLIP, Jak1 and STAT1 to mediate apoptosis in non-hemotopoietic cancer cells.

Lymphopoiesis

CD27 plays a role in lymphoid proliferation, differentiation, and apoptosis.

Michael D. Lockshin

Locksin's twin brother, Richard A. Lockshin, is an American cellular biologist known for his work on apoptosis.

MiR-338

miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK).

P53 upregulated modulator of apoptosis

When the inhibition of these is lifted, they result in the translocation of Bax and activation of mitochondrial dysfunction resulting in release of mitochondrial apoptogenic proteins cytochrome c, SMAC, and apoptosis-inducing factor (AIF) leading to caspase activation and cell death.

RANKL

This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), which indicated this protein may have a role in the regulation of cell apoptosis.

Semen quality

Males carrying Robertsonian translocations in their chromosomes have significantly higher degree of sperm cell apoptosis and lower concentration.

Transition state theory

Purine nucleoside phosphorylase (PNP) is an enzyme involved in the catabolism and recycling of nucleosides and is a target for the development of novel therapeutic agents for T-cell apoptosis in leukemia and in autoimmune diseases.

Tumstatin

It has been shown to increase apoptosis in HUVEC cells as well as HeLa cells.


see also