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The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues.
Human TGF-beta induced Ig-H3 (BIgH3) protein (4 FAS1 domains), where the FAS1 domains mediate cell adhesion through an interaction with alpha3/beta1 integrin; mutation in the FAS1 domains result in corneal dystrophy.
NO signalling has also been shown to control the motility of endothelial cells by regulating the expression of cell adhesion molecules ICAM-1.
Results from rat hippocampal gene chip data after acute administration of tetrahydrocannabinol (THC) showed an increase in the expression of transcripts encoding myelin basic protein, endoplasmic proteins, cytochrome oxidase, and two cell adhesion molecules: NCAM, and SC1; decreases in expression were seen in both calmodulin and ribosomal RNAs (Kittler et al., 2000).
Fibronectin, a glycoprotein involved in cell adhesion and growth
The members of the L1-family in humans are called L1 or L1cam, CHL1 (close homologue of L1), Neurofascin and NrCAM (NgCAM related cell adhesion molecule).
Three receptors for the H protein have been identified to date: complement regulatory molecule CD46, the signaling lymphocyte activation molecule (SLAM) and the cell adhesion molecule Nectin-4.
necl-1 : CADM3 (Cell adhesion molecule 3), TSLL1 (TSLC1-like 1), SynCAM3 (Synaptic cell adhesion molecule 3), IGSF4B (Immunoglobulin super family member 4B)
They include soluble forms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin).
CD2, a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells