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Dock4-Ex49 is a splice variant of the signalling protein Dock4 (Dedicator of cytokinesis 4).
Rac3 (Ras-related C3 botulinum toxin substrate 3) is a small (~21 kDa) monomeric GTP-binding protein G protein and is an important component of intracellular signalling pathways.
Ephrin receptors (EPHA1-10), components of cell signalling pathways involved in animal growth and development
Phosphorylation is a key reversible modification that regulates protein function, subcellular localization, complex formation, degradation of proteins and therefore cell signalling networks.
PLS is not considered hereditary when onset is in adulthood; however, juvenile primary lateral sclerosis (JPLS) has been linked to a mutation in the ALS2 gene which encodes the cell-signalling protein alsin.