The recruited eosinophils will degranulate releasing a number of cytotoxic molecules (including Major Basic Protein and eosinophil peroxidase) as well as produce a number of cytokines such as IL-5.
In order to keep the cytotoxic cells from killing cells just for presenting self-proteins, self-reactive T cells are deleted from the repertoire as a result of tolerance (also known as negative selection).
Steroids are often used in the treatment of AIED, as well as cytotoxic agents such as Cyclophosphamide and Methotrexate.
These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps, yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties.
However, two isoforms, the apoptosis-inducing membrane-bound form and the soluble form, are normal products whose production via alternative splicing is regulated by the cytotoxic protein TIA1.
The appearance of HIV-1-specific CD8+ cytotoxic T cells (CTLs) early after primo-infection has been correlated with the control of HIV-1 viremia.
Components of signalization pathway of IL-1R which are involved in cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like receptors (TLRs), and many forms of cytotoxic stress.
Since methylglyoxal is highly cytotoxic, the body developed several detoxification mechanisms.
Penostatin A is a cytotoxic metabolite produced by Penicillium.
globostellata has been shown to produce a wide variety of isomalabaricanes, a type of triterpene molecules with notable cytotoxic activity towards certain cancer cell lines.