In 1747, while serving as surgeon on HMS Salisbury, James Lind carried out a controlled experiment to develop a cure for scurvy.
Dr. Milliken is a co-author of the three volume Analysis of Messy Data series (Volume 1: Designed Experiments; Volume 2: Nonreplicated Experiments; Volume 3: Analysis of Covariance) and the co-author of the book SAS System for Mixed Models.
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He is known for his work on the convergence of the EM algorithm, resampling methods such as the bootstrap and jackknife, and industrial statistics, including design of experiments, and robust parameter design (Taguchi methods).
A crossover study, also referred to as a crossover trial, is a longitudinal study in which subjects receive a sequence of different treatments (or exposures).
Fisher particularly criticized Wald's work on the design of experiments, alleging ignorance of the basic ideas of the subject, as set out by Fisher and Frank Yates.