The aberrant epigenetic landscape of the cancer cell is characterized by a global genomic hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, an altered histone code for critical genes and a global loss of monoacetylated and trimethylated histone H4.
RhoC GTPase is overexpressed, possibly related to overexpression (hypomethylation) of caveolin-1 and -2.